Galectin-3 and Cardiac Function in Survivors of Acute Myocardial Infarction Weir et al: Galectin-3 Post-Infarction Remodeling
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Galectin-3 and cardiac function in survivors of acute myocardial infarction.
BACKGROUND Galectin-3 is a biomarker associated with inflammation and fibrosis that predicts adverse outcome and relates to biomarkers of extracellular matrix turnover in patients with heart failure, particularly when left ventricular (LV) systolic function is preserved. Whether galectin-3 is related to LV remodeling after acute myocardial infarction is unknown. METHODS AND RESULTS Circulatin...
متن کاملGalectin-3 and post-myocardial infarction cardiac remodeling.
This review summarizes the current literature regarding the involvement and the putative role(s) of galectin-3 in post-myocardial infarction cardiac remodeling. Post-myocardial infarction remodeling is characterized by acute loss of myocardium, which leads to structural and biomechanical changes in order to preserve cardiac function. A hallmark herein is fibrosis formation, both in the early an...
متن کاملGalectin-3 and sST2 in prediction of left ventricular ejection fraction after myocardial infarction.
BACKGROUND Fibrosis is a pivotal event in infarct repair and progressive remodeling after myocardial infarction (MI). Biomarkers may be used to monitor fibrosis, and therefore we evaluated the predictive value of galectin-3 and sST2 for cardiac remodeling after MI. METHODS Plasma galectin-3 and sST2 were measured in patients admitted with primary percutaneous coronary intervention (PCI) for a...
متن کاملGalectin-3, a marker of cardiac remodeling, is inversely related to serum levels of marine omega-3 fatty acids. A cross-sectional study
OBJECTIVE Marine polyunsaturated n-3 fatty acids (n-3 PUFA) may have cardioprotective effects and beneficial influence on the fibrotic process. We evaluated the associations between serum marine n-3 PUFA and selected biomarkers of fibrosis and cardiac remodeling in elderly patients with acute myocardial infarction. SETTING From the ongoing OMega-3 fatty acids in Elderly patients with Myocardi...
متن کاملBiomarkers Beyond the Natriuretic Peptides for Chronic Heart Failure: Galectin-3 and Soluble ST2
B-type natriuretic peptide (BNP) and NT-proBNP are widely used plasma biomarkers for the diagnosis of acute decompensated heart failure and prognosis for future cardiac disease. The clinical performance of these tests for management of chronic heart failure is somewhat limited by the markers' high biological variation. Biomarkers such as galectin-3 and soluble ST2 that reflect ongoing remodelin...
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تاریخ انتشار 2013